Understanding how EBV DNA changes in people with HIV to improve early cancer detection
Investigating the EBV methylome in PLWH: Discovery and Development of Novel EBV Diagnostics in Plasma and Saliva
This study is looking at how changes in the Epstein-Barr Virus (EBV) DNA might help us find EBV-related lymphomas earlier in people living with HIV, using easy-to-collect samples like blood and saliva, so we can improve diagnosis and treatment, especially for those who might not have easy access to healthcare.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10925381 on NIH RePORTER |
What this research studies
This research investigates the role of Epstein-Barr Virus (EBV) DNA methylation in people living with HIV (PLWH) and its connection to different types of EBV-related lymphomas. By analyzing patterns of DNA methylation, the study aims to develop new diagnostic tools that can detect these cancers earlier, potentially using samples from blood plasma and saliva. The research focuses on understanding how these epigenetic changes affect viral gene expression and could lead to better outcomes for patients. The goal is to create liquid biopsy diagnostics that are more accurate and accessible, especially for those in underserved communities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be at risk for developing EBV-related lymphomas.
Not a fit: Patients who do not have HIV or those without any risk factors for EBV-related lymphomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of EBV-related lymphomas in HIV patients, improving treatment outcomes and survival rates.
How similar studies have performed: There is emerging evidence that similar approaches using DNA methylation patterns have shown promise in other cancer detection studies, indicating potential for success in this area as well.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Ambinder, Richard Frederick — Johns Hopkins University
- Study coordinator: Ambinder, Richard Frederick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.