Understanding how Ebola virus proteins interact with the immune system
Official title: Defining how ubiquitination of Ebola viral proteins affect host-viral dynamics
Funded at Washington University · NIH-11034053 · Data updated 2026-11-12
This study is looking at how a specific protein from the Ebola virus affects the body's immune response, which could help us find better ways to treat and prevent Ebola.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $34,623 |
| NIH project number | 5F30AI181462-02 |
| Project ID | NIH-11034053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of Ebola virus exposure or those living in regions where Ebola outbreaks occur.
✕Less likely to help
Patients who are not at risk of Ebola virus exposure or those with no history of Ebola virus disease may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which the Ebola virus affects the host's immune response, particularly focusing on a viral protein called VP35. The study aims to explore how the ubiquitination of this protein influences its function and the overall viral replication process. By utilizing biochemical and structural biology techniques, the researchers will identify critical interactions between the virus and host factors that could lead to better therapeutic strategies. This work is essential for developing effective treatments and vaccines against Ebola virus disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for Ebola virus disease.
How similar studies have gone: Previous research has shown promise in understanding viral-host interactions, but this specific approach to studying Ebola virus dynamics is relatively novel.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Uwase, Grace — Washington University
- Study coordinator: Uwase, Grace
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.