Understanding how Ebola virus proteins help the virus enter cells
Dynamics and mechanisms of filovirus envelop glycoproteins
This study is looking at how the Ebola virus gets into human cells, focusing on specific parts of the virus, and aims to find new ways to treat or prevent Ebola infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10886761 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that allow the Ebola virus to enter human cells, focusing on the role of the virus's envelope glycoproteins. By using advanced techniques like single-molecule fluorescence, the team aims to uncover the dynamic events that occur during the virus's entry process. The study combines various scientific approaches, including virology, cellular biology, and biophysics, to create a detailed model of how the virus interacts with host cells. This understanding could lead to new treatments and preventive measures against Ebola outbreaks.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals at risk of Ebola virus exposure, such as healthcare workers or those living in outbreak regions.
Not a fit: Patients who are not at risk of Ebola virus exposure or those with no history of exposure to filoviruses may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies and vaccines to combat Ebola virus infections.
How similar studies have performed: Previous research has shown promise in understanding viral entry mechanisms, but this specific approach to studying filovirus glycoproteins is relatively novel.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Munro, James B — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Munro, James B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.