Understanding how Ebola virus causes severe inflammation and illness
Mechanisms of Ebola virus-mediated inflammatory activation linked to pathogenesis
This study is looking at how the Ebola virus causes the body to react strongly and sometimes harmfully, and it's focused on a specific part of the virus to help find better treatments for people affected by Ebola during outbreaks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10673795 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the Ebola virus triggers severe inflammatory responses in the body, leading to serious health complications. By studying the viral protein VP40, which is crucial for the virus's life cycle, the research aims to uncover how it activates inflammatory pathways in human cells. The goal is to develop effective treatments that can mitigate the harmful immune responses associated with Ebola virus disease, particularly during outbreaks. This work is essential for improving patient outcomes in future Ebola outbreaks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to the Ebola virus or are at risk of infection during outbreaks.
Not a fit: Patients who are not at risk of Ebola virus exposure or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that effectively manage the severe inflammatory responses caused by Ebola virus, potentially saving lives during outbreaks.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms of disease, suggesting that this approach could yield valuable insights into Ebola virus pathogenesis.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Barry, Michael a — Mayo Clinic Rochester
- Study coordinator: Barry, Michael a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.