Understanding how Ebola virus affects the immune system
Molecular Mechanisms of the Dysregulated Immune Response to Ebola Virus
This study is looking at how the Ebola virus affects the immune system's ability to fight off the infection, which can sometimes lead to serious problems, and it's for anyone interested in understanding how our bodies respond to this virus.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11105942 on NIH RePORTER |
What this research studies
This research investigates how Ebola virus infection alters immune cell responses at various biological levels, including transcriptional, posttranscriptional, and posttranslational changes. By examining these changes, the research aims to uncover why the immune system sometimes fails to respond effectively, leading to severe complications like immune paralysis and hyperinflammation. The project involves multiple research components that will work together to analyze samples from infected cells and nonhuman primates, ensuring a comprehensive understanding of the immune response to Ebola. Advanced techniques such as massive parallel sequencing and mass spectrometry will be utilized to gather and analyze data.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been exposed to or infected with the Ebola virus, particularly those experiencing severe immune responses.
Not a fit: Patients who have not been exposed to the Ebola virus or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Ebola virus disease by enhancing our understanding of immune dysfunction.
How similar studies have performed: Previous research has shown success in understanding immune responses to viral infections, but this specific approach to Ebola virus is relatively novel.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Bukreyev, Alexander — University of Texas Med Br Galveston
- Study coordinator: Bukreyev, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.