Understanding how EBF1 affects breast cancer progression
Characterize the role of EBF1 in breast cancer progression
This study is looking at how a protein called EBF1 affects the growth of aggressive basal-like breast cancer, especially in low-oxygen environments, to help find better treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10704004 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called EBF1 in the progression of basal-like breast cancer, a particularly aggressive form of the disease. The study aims to understand how EBF1 influences mitochondrial function and metabolism in cancer cells, especially under low-oxygen conditions. Researchers will explore the relationship between EBF1 and another protein, HIF1α, to see how they interact and affect cancer cell survival. By using both human samples and mouse models, the research seeks to uncover new insights that could lead to better treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with basal-like breast cancer who may benefit from novel treatment approaches.
Not a fit: Patients with other types of breast cancer or those who do not have breast cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating basal-like breast cancer.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could be beneficial.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Wu, Yadi — University of Kentucky
- Study coordinator: Wu, Yadi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.