Understanding how early stage melanomas change and interact with the immune system
Dissecting Phenotype Switching in Early Stage Melanomas
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10894881
This study is looking at how early melanoma, a type of skin cancer, develops and how the body's immune system reacts to it by using special mice that have human-like immune cells, which could help us understand the disease better and find new ways to fight it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10894881 on ClinicalTrials.gov |
What this research studies
This research investigates the early stages of melanoma, a serious skin cancer, by using advanced mouse models that closely mimic human disease. The team will create humanized mice that have human immune cells and then expose them to melanoma cells to observe how tumors develop and how the immune system responds. By studying these interactions, the researchers aim to uncover the molecular mechanisms that drive tumor progression and immune evasion in early melanomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early stage melanoma who are interested in understanding their disease better.
Not a fit: Patients with advanced melanoma or those who have already received extensive treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and treatment of melanoma, potentially improving patient outcomes.
How similar studies have performed: While there has been significant research on melanoma, this approach using humanized mouse models to study early stage disease is relatively novel and has not been extensively tested.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHOBER, MARKUS — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: SCHOBER, MARKUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.