Understanding how early skin issues affect allergies in children
Official title: SUNBEAM Birth Cohort: Deciphering the role of early life skin dysfunction in development of the allergic march
Funded at National Jewish Health · NIH-10802027 · Data updated 2026-11-12
This study is looking at how skin problems in babies, like eczema, might lead to allergies and asthma later on, and it’s for parents who want to understand why some kids with skin issues develop more allergies while others don’t.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | September 6, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,297,775 |
| NIH project number | 1U01AI173502-01A1 |
| Project ID | NIH-10802027 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants and young children diagnosed with atopic dermatitis or other skin conditions.
✕Less likely to help
Patients who do not have any history of allergic diseases or skin conditions may not benefit from this research.
What this research studies
This research investigates the connection between early life skin conditions, such as atopic dermatitis, and the development of allergic diseases like food allergies and asthma in children. By examining different biological mechanisms in the skin, the study aims to identify why some infants with skin issues develop further allergies while others do not. The research will utilize both clinical observations and animal models to explore how skin barrier dysfunction and inflammation contribute to allergic responses. This comprehensive approach seeks to uncover the underlying factors that drive the 'allergic march' in young children.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for allergic diseases in children.
How similar studies have gone: Previous research has shown promising results in understanding the links between skin conditions and allergies, but this specific approach to studying the allergic march is relatively novel.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Seibold, Max a — National Jewish Health
- Study coordinator: Seibold, Max a
Related research
Other NIH-funded projects on the same topics.
-
Predictive models for BeS and CBD in exposed workers
Aimed at people exposed to beryllium, this project will build models to identify who is at risk for beryllium sensitization and Chronic Beryllium Disease using lung samples and data.
-
Understanding how early skin biology affects the development of allergies in children
A study with infants and young children aims to understand why some kids with eczema (atopic dermatitis) go on to develop food allergies and asthma, by looking at skin biology and immune patterns still early in life.
-
Rare airway cells and how they affect lung infections after a viral illness
This NIH grant looks at a rare airway cell type called M cells to see how they influence secondary bacterial infections after a viral lung illness.
-
Obinutuzumab for CTD-Related Interstitial Lung Disease in adults
This project tests whether the anti-B cell therapy obinutuzumab can help adults with connective tissue disease–related ILD who are on mycophenolate therapy.
-
Effects of Temperature Fluctuation on the Skin Barrier (K08)
A clinician-scientist is being mentored over 5 years to understand how changes in temperature affect the skin barrier and the development of allergies in children.
-
Precision tapering of dupilumab in asthma for safer, cost-saving interval extension
We’re testing if adults with well-controlled asthma on dupilumab can safely extend the time between injections to reduce costs and burden.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.