Understanding how early placental cells develop and their impact on pregnancy outcomes
Mechanisms of trophoblast lineage formation: Impact on postimplantation placental development
This study is looking at how certain cells that help form the placenta develop in early pregnancy, using mouse embryos and human stem cells, to better understand why some pregnancies might not succeed.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10376746 on NIH RePORTER |
What this research studies
This research investigates the formation of trophoblast cells, which are crucial for the development of the placenta in mammals. By using mouse embryos and human embryonic stem cells, the study aims to uncover the genetic mechanisms that guide the differentiation of these cells during early pregnancy. The research focuses on a specific transcription factor, TFAP2C, which is believed to play a vital role in ensuring proper placental development. Understanding these processes could help identify causes of implantation failure and miscarriage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing difficulties with conception or those who have had recurrent miscarriages.
Not a fit: Patients who are not trying to conceive or who have no history of pregnancy loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing miscarriages and enhancing fertility treatments.
How similar studies have performed: Other research has shown promising results in understanding early placental development, making this approach both relevant and potentially impactful.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Knott, Jason Glenn — Michigan State University
- Study coordinator: Knott, Jason Glenn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.