Understanding how early pancreatic lesions develop into cancer
TBEL Project 1
This study is looking at the early signs of pancreatic cancer to understand what makes certain growths in the pancreas turn into cancer, and it’s for patients who might help by sharing their samples or information.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10922843 on NIH RePORTER |
What this research studies
This research investigates the early stages of pancreatic cancer development, focusing on two types of precursor lesions: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). The study aims to identify the factors that influence whether these lesions progress to invasive pancreatic ductal adenocarcinoma (PDAC). By examining the role of specific genetic mutations and the interactions between tumor cells and surrounding fibroblasts, the research seeks to uncover critical insights into cancer progression. Patients may be involved in providing samples or data that help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplasm (IPMN).
Not a fit: Patients with advanced pancreatic cancer or those without any precursor lesions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of which patients with pancreatic lesions are at risk of developing cancer, potentially allowing for earlier interventions.
How similar studies have performed: Previous research has shown promise in understanding the role of genetic mutations in cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Pasca Di Magliano, Marina — University of Tx Md Anderson Can Ctr
- Study coordinator: Pasca Di Magliano, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.