Understanding how early lung inflammation affects newborns' immune responses
Official title: Regulation of Neonatal Lung Inflammation by Novel Innate Immune Mechanisms
Funded at University of Michigan at Ann Arbor · NIH-10977129 · Data updated 2026-11-12
This study is looking at how the body's natural defenses in newborns can cause lung inflammation that might lead to breathing problems, like bronchopulmonary dysplasia (BPD), especially when they come into contact with certain germs, and it aims to understand how this affects the lungs of premature babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $600,761 |
| NIH project number | 1R01HL167716-01A1 |
| Project ID | NIH-10977129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants who are at risk of developing bronchopulmonary dysplasia due to early-life inflammation.
✕Less likely to help
Patients who are full-term infants or those without any history of lung inflammation may not benefit from this research.
What this research studies
This research investigates the role of innate immune mechanisms in neonatal lung inflammation, particularly focusing on how inflammation in early life can lead to bronchopulmonary dysplasia (BPD). The study aims to explore how exposure to certain inflammatory triggers, like bacterial components, can activate specific immune cells in the lungs of newborns. By examining the interactions between these immune cells and their targets, the research seeks to uncover the pathways that contribute to lung damage and impaired development in premature infants.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating lung diseases in premature infants.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in neonatal conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Popova, Antonia Petrova — University of Michigan at Ann Arbor
- Study coordinator: Popova, Antonia Petrova
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.