Understanding how early life microbiota affects lung health
Official title: Establishing lifelong trajectories of pulmonary health
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11034696 · Data updated 2026-11-12
This study looks at how having good bacteria in the lungs during infancy can help keep kids' lungs healthy as they grow up, especially for those who might face breathing problems later on, and it also considers how early antibiotic use might change this helpful bacteria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | March 15, 2025 |
| Project end | February 29, 2032 |
| Funding year | 2025 |
| Award (this year) | $915,924 |
| NIH project number | 1R35HL177131-01 |
| Project ID | NIH-11034696 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and young children who have experienced antibiotic treatment and are at risk for respiratory issues.
✕Less likely to help
Patients who are adults or those without a history of antibiotic use or respiratory issues may not benefit from this research.
What this research studies
This research investigates how the colonization of the lungs by beneficial bacteria during infancy influences long-term lung health. It focuses on the immune responses of lung cells and how these are affected by early antibiotic use, which can disrupt healthy microbial communities. By studying these interactions, the research aims to identify new therapeutic strategies to improve lung health in children, particularly those at risk for chronic respiratory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung health and prevent chronic respiratory diseases in children.
How similar studies have gone: Other research has shown promising results in understanding the role of microbiota in health, suggesting that this approach could yield significant insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Deshmukh, Hitesh — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Deshmukh, Hitesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.