Understanding how early life inflammation affects immune responses
Official title: Decoding mechanisms of early life inflammation
Funded at Icahn School of Medicine at Mount Sinai · NIH-11223879 · Data updated 2026-11-12
This study is looking at how newborns' immune systems respond to things like allergens and inflammation, using a special mouse model, to help us find better treatments for skin conditions like atopic dermatitis in young children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 11, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $797,735 |
| NIH project number | 1R01AI184905-01A1 |
| Project ID | NIH-11223879 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants and young children who are at risk of developing atopic dermatitis or other allergic conditions.
✕Less likely to help
Patients who are adults or those who do not have a history of allergic conditions may not benefit from this research.
What this research studies
This research investigates the immune responses of newborns, particularly focusing on how their bodies react to allergens and inflammation. By using a novel mouse model, the study aims to uncover the mechanisms that lead to heightened immune reactions in infants compared to adults. The goal is to better understand the innate and adaptive immune systems during early life, which could inform the development of more effective treatments for conditions like atopic dermatitis. The findings may lead to new therapeutic strategies tailored specifically for young children suffering from inflammatory skin disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for infants suffering from atopic dermatitis and other inflammatory conditions.
How similar studies have gone: Other research has shown promise in understanding immune responses in early life, but this specific approach using a novel mouse model is relatively new and untested.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Naik, Shruti — Icahn School of Medicine at Mount Sinai
- Study coordinator: Naik, Shruti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.