Understanding how early-life immune cells respond to infections
Targetable pathways driving sub-optimal early-life CD8 T cell responses
This study is looking at how the immune cells called CD8 T cells work in young children, especially when they face serious viral infections, to find ways to help their immune systems fight better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10887226 on NIH RePORTER |
What this research studies
This research investigates the unique biology of CD8 T cells in young children, particularly how these immune cells respond to severe viral infections. The study aims to uncover the molecular mechanisms that drive the behavior of these cells, which are crucial for fighting off infections but can also contribute to disease. By examining the differences between neonatal and adult CD8 T cells, the research seeks to identify potential therapeutic targets to improve immune responses in young patients. The methodology includes advanced techniques like ATAC sequencing to analyze chromatin accessibility and gene expression in these immune cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants and young children under five years old who are at risk for severe viral infections.
Not a fit: Patients over the age of five or those with unrelated immune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for severe viral infections in young children, potentially reducing mortality and morbidity rates.
How similar studies have performed: Previous research has shown promise in understanding immune responses in early life, but this specific approach focusing on CD8 T cells in neonates is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Brodsky, Nina — Yale University
- Study coordinator: Brodsky, Nina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.