Understanding how early life factors affect allergies and asthma in children
Official title: Identification of Early Metabolomic and Immune Endotypes of Allergy and Asthma: An Integrated Multiomics Approach
Funded at Trustees of Indiana University · NIH-10904907 · Data updated 2026-11-12
This study is looking at how things like diet and environment during pregnancy and early life can affect babies' metabolism and immune systems, helping us understand why some infants might develop allergies and asthma later on.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $162,000 |
| NIH project number | 5K01HL149989-05 |
| Project ID | NIH-10904907 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and young children who are at risk for developing allergies or asthma due to environmental exposures.
✕Less likely to help
Patients who are older children or adults, or those without a history of allergies or asthma, may not benefit from this research.
What this research studies
This research investigates how metabolic and immune changes in infants, influenced by environmental factors during pregnancy and early life, contribute to allergies and asthma. By analyzing metabolites and immune responses in infants, the study aims to identify specific patterns that predict the risk of developing wheezing and allergic conditions. The approach combines various biological data to provide a comprehensive view of the underlying mechanisms involved in these conditions, potentially leading to earlier identification and intervention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and prevention strategies for allergies and asthma in children.
How similar studies have gone: Previous research has shown promise in using integrated omics approaches to understand chronic diseases, suggesting that this method could be effective for studying childhood allergies and asthma.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Turi, Kedir Nesha — Trustees of Indiana University
- Study coordinator: Turi, Kedir Nesha
Related research
Other NIH-funded projects on the same topics.
-
Childhood Allergy and the Neonatal Environment: Early Life Airways and Asthma
A long-term study following newborns to age 5 to understand how early-life nose and airway biology, immune development, and the environment influence asthma risk.
-
Role of a special interferon-responsive T cell in allergies and asthma
A study explores a unique interferon-responsive T cell type that may influence allergies and asthma, aiming to understand why some people become allergic and how this T cell subset could affect airway inflammation.
-
Children's Allergy and Asthma Data Hub
A national data hub will pool and harmonize child allergy and asthma cohort data to help researchers discover ways to prevent asthma in kids.
-
Viral and Host Factors in Infant and Child Allergy and Asthma
This grant explores why some babies and young children develop asthma by studying how viruses, environment, and airway cells interact from birth.
-
Children's Allergy and Asthma Data Hub (CADRE)
This project builds a shared data hub that combines many childhood allergy and asthma birth-study records so researchers can find early-life factors that change a child's risk of asthma.
-
How microRNAs control allergy and asthma
This work looks at tiny gene-regulating molecules called microRNAs to find molecular ways to reduce allergic inflammation in people with asthma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.