Understanding how early life adversity affects the opioid system in children
Dysregulation of the opioid system in early life adversity
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10886629
This study looks at how tough experiences in childhood, like neglect or abuse, can affect the brain's ability to handle stress and emotions, using mice to understand how these early challenges might lead to problems later in life.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10886629 on ClinicalTrials.gov |
What this research studies
This research investigates how childhood maltreatment influences the brain's beta-endorphin signaling pathway, which may lead to emotional and behavioral issues later in life. Using a mouse model that simulates complex trauma, the study examines the effects of unpredictable maternal care on brain activity and behavior. By focusing on specific neurons that respond to distress signals, the research aims to uncover the biological mechanisms linking early adversity to long-term emotional dysregulation and attachment issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents aged 12-20 who have experienced childhood maltreatment or trauma.
Not a fit: Patients who have not experienced any form of childhood adversity or trauma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions for children who have experienced trauma, improving their emotional and behavioral outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of the opioid system in emotional regulation, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIETRICH, MARCELO — YALE UNIVERSITY
- Study coordinator: DIETRICH, MARCELO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.