Understanding how early injuries affect pain in children
Sensitization of developing sensory neurons after incision
This study looks at how injuries in young kids can cause long-lasting pain by exploring how their nerves and immune cells work differently than in adults, with the goal of finding better treatments for children who have ongoing pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11060966 on NIH RePORTER |
What this research studies
This research investigates how early life injuries can lead to persistent pain in children by examining the role of sensory neurons and immune cells, particularly macrophages. It focuses on the unique characteristics of the developing nervous system in children and how these systems respond differently to injuries compared to adults. By studying the mechanisms of pain development in pediatric patients, the research aims to uncover potential new treatments tailored for children suffering from chronic pain.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-11 years who experience chronic or persistent pain.
Not a fit: Patients who are adults or do not have a history of early life injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies specifically designed for children.
How similar studies have performed: Previous research has shown promising results in understanding pain mechanisms in adults, but this approach focusing on pediatric pain is relatively novel.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Jankowski, Michael P — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Jankowski, Michael P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.