Understanding how early embryonic cells develop into different types
Mechanisms of epiblast and primitive endoderm segregation
['FUNDING_R01'] · PRINCETON UNIVERSITY · NIH-11094769
This study looks at how mouse embryos start to develop by examining how their cells become two important types: the epiblast and the primitive endoderm, which are crucial for forming a healthy organism.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-11094769 on ClinicalTrials.gov |
What this research studies
This research investigates the early stages of embryonic development, focusing on how cells in the preimplantation mouse embryo differentiate into two key lineages: the epiblast and the primitive endoderm. By observing these processes at a cellular level, the research aims to uncover the molecular and cellular mechanisms that guide this differentiation. The approach involves advanced techniques such as ATAC sequencing to analyze gene expression patterns and cell behavior during this critical phase of development. This could provide insights into how cells organize themselves to form functional structures in an organism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the biological mechanisms of embryonic development or those affected by conditions related to developmental abnormalities.
Not a fit: Patients with fully developed conditions unrelated to embryonic development may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of developmental biology, potentially leading to advancements in regenerative medicine and treatments for developmental disorders.
How similar studies have performed: Other research has shown success in understanding cell differentiation processes, but this specific approach using ATAC sequencing in early embryonic development is relatively novel.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POSFAI, ESZTER — PRINCETON UNIVERSITY
- Study coordinator: POSFAI, ESZTER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.