Understanding how early egg cell formation occurs
Novel regulation of early follicle formation
['FUNDING_R01'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-10669562
This study is looking at how certain proteins and hormones help turn basic cells into the important cells needed for healthy egg development, which could help us understand why some women have trouble getting pregnant due to conditions like premature ovarian failure or Turner Syndrome.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-10669562 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that lead to the formation of primordial follicles, which are essential for female fertility. It focuses on the roles of specific proteins and hormones, such as BMP2 and GDF9, in transforming undifferentiated cells into granulosa cells, which are crucial for egg development. By studying these processes, the research aims to uncover the molecular basis of ovarian dysfunctions that lead to infertility in women with conditions like premature ovarian failure and Turner Syndrome. The approach includes manipulating gene expressions and observing the effects on cell interactions and follicle formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are women with conditions such as premature ovarian failure or Turner Syndrome who are experiencing infertility.
Not a fit: Patients with normal ovarian function or those not experiencing fertility issues are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for women facing infertility due to ovarian dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding follicle formation, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROY, SHYAMAL K. — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: ROY, SHYAMAL K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.