Understanding how early chemical exposure affects bladder control, especially in people with autism
Impact of developmental polychlorinated biphenyls on bladder contractility
This research explores how early exposure to certain environmental chemicals might contribute to bladder control issues, particularly for individuals with Autism Spectrum Disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11178493 on NIH RePORTER |
What this research studies
Many people, especially those with Autism Spectrum Disorder, experience bladder control problems that significantly impact their daily lives. Current treatments often only address symptoms because we don't fully understand what causes these issues. This research looks into whether early exposure to certain environmental chemicals, like polychlorinated biphenyls (PCBs), might play a role in developing these bladder problems. We want to learn how these chemicals might affect the way bladder muscles contract, specifically by influencing important channels that help regulate bladder function. Understanding these connections could help us find new ways to prevent or treat bladder control issues.
Who could benefit from this research
Good fit: This research is relevant to adults aged 21 and older who have Autism Spectrum Disorder and experience lower urinary tract symptoms.
Not a fit: Patients who do not experience lower urinary tract symptoms or do not have Autism Spectrum Disorder may not directly benefit from the findings of this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the causes of bladder control problems in individuals with Autism Spectrum Disorder, potentially paving the way for new and more effective treatments.
How similar studies have performed: While environmental toxicants are known to affect other organs, this research explores a novel connection between early chemical exposure and bladder control issues, building on preliminary findings in animal models.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Stietz, Kimberly Preston Keil — University of Wisconsin-Madison
- Study coordinator: Stietz, Kimberly Preston Keil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.