Understanding how early brain dysfunction affects autism symptoms in mice
Mechanisms and pathogenic role of early corticostriatal dysfunction in Shank3B-/- mice
This study is looking at how certain brain changes in mice with a genetic alteration might help us understand the motor and thinking challenges faced by people with autism, which could lead to better treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10954720 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind motor and cognitive deficits in autism spectrum disorders (ASD) by studying mice with a specific genetic alteration (Shank3B-/-). The team will explore how the development of brain circuits is disrupted in these mice, particularly focusing on the corticostriatal pathways that are crucial for behavior and cognition. By using advanced genetic techniques, they aim to identify the specific changes in brain function that contribute to the symptoms of autism, which could lead to new insights into treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with genetic factors similar to the Shank3B-/- model.
Not a fit: Patients without autism spectrum disorder or those whose conditions do not involve similar genetic mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of autism and potentially new therapeutic strategies for individuals with ASD.
How similar studies have performed: Other research has shown promising results in understanding genetic factors in autism, but this specific approach focusing on corticostriatal dysfunction is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Peixoto, Rui — University of Pittsburgh at Pittsburgh
- Study coordinator: Peixoto, Rui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.