Understanding how early bladder cancer progresses and how to predict it
Project 1
This study is looking at how non-muscle-invasive bladder cancer might turn into a more serious form of the disease, focusing on the role of certain cells in the body that interact with the immune system, to help doctors better understand which patients might be at higher risk of this progression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10708897 on NIH RePORTER |
What this research studies
This research focuses on non-muscle-invasive bladder cancer (NMIBC) and aims to identify the mechanisms that lead to its progression to muscle-invasive disease. By studying the role of immunofibroblasts and their interaction with immune cells, the project seeks to develop a better understanding of how these cells contribute to tumor response and progression. The researchers will utilize advanced techniques, including single-cell RNA sequencing, to analyze tissue samples and identify key cellular interactions. This work could lead to improved risk stratification for patients with NMIBC, helping to identify those at higher risk of progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with non-muscle-invasive bladder cancer who are at risk of progression to muscle-invasive disease.
Not a fit: Patients with muscle-invasive bladder cancer or those without a diagnosis of bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and management strategies for patients with non-muscle-invasive bladder cancer.
How similar studies have performed: Previous research has shown promise in understanding tumor microenvironments and immune interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Chan, Keith Syson — Methodist Hospital Research Institute
- Study coordinator: Chan, Keith Syson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.