Understanding how early adenomas and surrounding colon tissue contribute to cancer progression
Features of the early adenoma and adjacent colon that drive progression: the role of mutation burden in normal tissue, senescent cells, and tumor clonal architecture
This study is looking at what causes early growths in the colon, called adenomas, to turn into colorectal cancer, using mice to find out how certain cells might affect this process, with the hope of helping people at higher risk get better care and prevention.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10926953 on NIH RePORTER |
What this research studies
This research investigates the factors that lead to the progression of early adenomas, which are precursors to colorectal cancer (CRC). By using mouse models, the study examines how pre-existing mutant clones and the presence of senescent cells in the colon can influence adenoma development and progression. The goal is to identify specific attributes that can be detected in individuals, allowing for personalized risk assessments and targeted surveillance for those at high risk of developing CRC. If successful, this research could lead to new preventive strategies and treatments for at-risk patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of colorectal cancer or those who have been identified as having early adenomas.
Not a fit: Patients who do not have any history of adenomas or colorectal cancer and are not at risk may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help identify individuals at high risk for colorectal cancer and enable early interventions to prevent cancer development.
How similar studies have performed: Other research has shown promise in identifying genetic and environmental factors that contribute to cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Halberg, Richard Brott — Fred Hutchinson Cancer Center
- Study coordinator: Halberg, Richard Brott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.