Understanding how ear cells help us hear
Membrane properties of the OHC system
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11089327
This research aims to understand how a special protein in our inner ear helps us hear by changing shape.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11089327 on ClinicalTrials.gov |
What this research studies
Our inner ear contains tiny cells called Outer Hair Cells (OHCs) that are crucial for amplifying sounds, allowing us to hear clearly. A protein called prestin acts like a motor in these OHCs, rapidly changing shape to boost sound signals. This project builds on previous work to map the structure of prestin when it's in a contracted state. Researchers will use advanced imaging techniques and computer simulations to discover how prestin's structure changes when it expands, which is important for its role in hearing. By understanding these shape changes, we can learn more about how our ears process sound.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but it is relevant to anyone interested in the biological mechanisms of hearing and hearing loss.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a clinical trial would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of how hearing works and why some people experience hearing loss, potentially guiding future treatments.
How similar studies have performed: This project builds upon previous successful efforts to define the structure of prestin, indicating a progressive and established line of inquiry.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANTOS-SACCHI, JOSEPH R — YALE UNIVERSITY
- Study coordinator: SANTOS-SACCHI, JOSEPH R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.