Understanding how E2F transcription factors control cell growth in cancer
Project 3: Defining and targeting mechanisms of E2F transcription factor regulation
['FUNDING_P01'] · STANFORD UNIVERSITY · NIH-11046674
This study is looking at how certain proteins called E2F help control cell growth and division, which is important for understanding cancer, and it aims to find new ways to treat the disease by figuring out how these proteins work.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11046674 on ClinicalTrials.gov |
What this research studies
This research investigates the role of E2F transcription factors in regulating the cell cycle and their implications in cancer. It aims to uncover how E2F interacts with chromatin to activate gene expression necessary for cell division. The study employs structural, biochemical, and cellular assays to explore the mechanisms of E2F regulation, including its posttranslational modifications and interactions with other proteins. By understanding these processes, the research seeks to identify potential therapeutic targets for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers characterized by dysregulation of the E2F transcription factors.
Not a fit: Patients with cancers not associated with E2F dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer cell growth and improving treatment outcomes.
How similar studies have performed: Other research has shown promising results in targeting transcription factors for cancer therapy, indicating that this approach has potential.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUBIN, SETH MICHAEL — STANFORD UNIVERSITY
- Study coordinator: RUBIN, SETH MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell, Cancer Control