Understanding how dysfunctional HDL cholesterol contributes to heart disease
Human Atherogenesis with Underlying Dysfunctional HDL-Free Cholesterol
This study is looking at how a type of cholesterol called HDL might actually play a role in heart disease, especially in people who have high levels of it, and it's using mice to help figure out how this works so we can find better ways to treat heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11023079 on NIH RePORTER |
What this research studies
This research investigates the relationship between high-density lipoprotein cholesterol (HDL-C) and atherosclerotic cardiovascular disease (ASCVD). It focuses on how HDL functions in transferring free cholesterol from arterial-wall macrophages, which may be more predictive of ASCVD than HDL-C levels alone. Using a mouse model that mimics human high-HDL conditions, the study aims to uncover the mechanisms behind the paradox of high HDL levels correlating with increased ASCVD risk. By exploring these mechanisms, the research seeks to identify potential therapeutic targets for better managing heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with high levels of HDL cholesterol who are at risk for atherosclerotic cardiovascular disease.
Not a fit: Patients with low HDL cholesterol or those without any cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively reduce the risk of heart disease in patients with high HDL cholesterol.
How similar studies have performed: Previous research has indicated that understanding HDL function can lead to breakthroughs in cardiovascular treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Pownall, Henry J. — Methodist Hospital Research Institute
- Study coordinator: Pownall, Henry J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.