Understanding how dynein proteins help transport materials within cells
The Mechanism and Regulation of the Dynein Transport Machinery
This study is looking at how a special protein called dynein helps move things around inside our cells and how it's controlled, which could help us understand important processes that affect our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11091137 on NIH RePORTER |
What this research studies
This research investigates the role of dynein, a motor protein, in transporting materials within cells and its regulation. By using advanced techniques like cryo-electron microscopy and single-molecule imaging, the researchers aim to uncover how dynein is activated and how it moves along microtubules, which are essential for cellular organization and function. The study focuses on the interactions between dynein and accessory proteins that help regulate its activity, providing insights into cellular processes that are critical for health and disease.
Who could benefit from this research
Good fit: Patients with conditions linked to cellular transport issues, such as neurodegenerative diseases or certain genetic disorders, may benefit from this research.
Not a fit: Patients with conditions unrelated to cellular transport mechanisms are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cellular transport dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding motor proteins, indicating that this approach could yield valuable insights.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Yildiz, Ahmet — University of California Berkeley
- Study coordinator: Yildiz, Ahmet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.