Understanding how dynein proteins drive ciliary movement
Structural basis of dynein-driven ciliary motility
This study is looking at how certain proteins help tiny hair-like structures called cilia move, which is important for many cell functions, and it could help us understand diseases that happen when cilia don’t work properly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10928255 on NIH RePORTER |
What this research studies
This research investigates the role of dynein proteins in the movement of cilia, which are essential for various cellular functions. By using model organisms like T. thermophila and C. reinhardtii, the team aims to uncover the atomic details of ciliary assembly and motility. The research employs advanced techniques such as cryo-electron microscopy and computational modeling to explore how dynein proteins interact and function during ciliary beating. This could lead to a better understanding of diseases caused by ciliary dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with primary ciliary dyskinesia or other ciliopathies caused by dynein mutations.
Not a fit: Patients with conditions unrelated to ciliary dysfunction or those without genetic mutations affecting dynein are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the mechanisms behind ciliopathies, potentially leading to new treatments for related congenital disorders.
How similar studies have performed: Previous research has shown success in understanding ciliary function through similar molecular and biophysical approaches, indicating a promising avenue for this investigation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Zhang, Kai Jack — Yale University
- Study coordinator: Zhang, Kai Jack
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.