Understanding how Dynein motor proteins work in cells
Investigating the in vivo regulation of Dynein activity
This study is looking at how a special protein called Dynein helps move important materials inside cells, using fruit fly egg chambers to learn how it works and what helpers it needs, which could help us understand diseases caused by problems with this transport system.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11071198 on NIH RePORTER |
What this research studies
This research investigates the regulation of Dynein, a motor protein that transports essential cellular materials, in living cells. By using the Drosophila egg chamber as a model, the study aims to uncover how Dynein is activated and which cargo adaptors are necessary for its function. This approach will provide insights into the mechanisms of cellular transport and polarity, which are crucial for cell health and function. The findings could have implications for understanding diseases related to cellular transport dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodegenerative diseases, particularly those with Amyotrophic Lateral Sclerosis.
Not a fit: Patients with conditions unrelated to cellular transport or neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular transport mechanisms that may inform treatments for conditions like Amyotrophic Lateral Sclerosis.
How similar studies have performed: While the specific approach of studying Dynein in vivo is less explored, related research on motor proteins has shown promise in understanding cellular transport mechanisms.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Allen, Phylicia Angela — Augusta University
- Study coordinator: Allen, Phylicia Angela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.