Understanding how dynein motor proteins work in cells
Regulation of cytoplasmic dynein in vivo
This study is looking at how a special protein called dynein helps move important materials inside cells, using a type of fungus to learn more about how it works and what controls it, which could help us understand its role in health issues like neurodegenerative diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10906809 on NIH RePORTER |
What this research studies
This research investigates the function of cytoplasmic dynein-1, a motor protein that transports essential cellular materials within eukaryotic cells. By using a filamentous fungus called Aspergillus nidulans, the study aims to uncover how dynein's activity is regulated by various adapter proteins and other factors. The research involves observing dynein's interactions with microtubules and the cellular components it transports, which could provide insights into its role in health and disease, particularly in neurodegenerative conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative disorders, particularly those affected by ALS.
Not a fit: Patients with non-neurological conditions or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurodegenerative diseases like amyotrophic lateral sclerosis (ALS).
How similar studies have performed: Previous research has shown promising results in understanding motor protein functions, indicating that this approach could yield valuable insights.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Xiang, Xin — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Xiang, Xin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.