Understanding how dynein motor proteins are regulated in cells
Mechanisms of dynein regulation
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10878809
This study is looking at how a key protein called dynein works to move things around in our cells, which is important because problems with dynein are connected to brain disorders; the researchers will use special imaging techniques to see how dynein interacts with other proteins in both still and living cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10878809 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control dynein, a crucial motor protein responsible for moving cellular components. By using advanced techniques such as proteomics, biochemistry, and fluorescence microscopy, the team aims to uncover how dynein interacts with various regulatory proteins. This understanding is vital because dysregulation of dynein is linked to several neurodevelopmental and neurodegenerative disorders. The research will involve both fixed and live cell imaging to observe dynein's behavior in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental or neurodegenerative disorders, particularly those associated with dynein mutations.
Not a fit: Patients with conditions unrelated to dynein dysfunction or those not experiencing neurodevelopmental or neurodegenerative disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapeutic strategies for treating neurodegenerative diseases linked to dynein dysfunction.
How similar studies have performed: Other research has shown promising results in understanding motor protein regulation, indicating that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DESANTIS, MORGAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: DESANTIS, MORGAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Degenerative Neurologic Disorders, Disease, Disorder