Understanding how dynamin proteins help cells move and communicate.
Structural basis of dynamin-mediated membrane fission actin bundling and interaction with binding partners.
['FUNDING_OTHER'] · PRINCETON UNIVERSITY · NIH-10758573
This study is looking at how certain proteins called dynamins help cells move and take in materials, which could lead to better understanding of cancer behavior and treatments that might help patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PRINCETON UNIVERSITY (nih funded) |
| Locations | 1 site (Princeton, UNITED STATES) |
| Trial ID | NIH-10758573 on ClinicalTrials.gov |
What this research studies
This research investigates the role of dynamin proteins in the process of membrane fission, which is crucial for cell functions like endocytosis and cell migration. By studying the structural and biophysical properties of dynamin, the research aims to uncover how these proteins bundle actin filaments and interact with other proteins during cellular processes. Patients may benefit from insights gained about how these mechanisms affect cancer cell behavior and treatment responses. The research employs both in vitro and in vivo methodologies to explore these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be influenced by cellular migration and membrane dynamics.
Not a fit: Patients with non-malignant conditions or those not affected by cellular motility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer cell movement and communication, potentially improving treatment outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of dynamin in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Princeton, UNITED STATES
- PRINCETON UNIVERSITY — Princeton, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIMAH, JOHN — PRINCETON UNIVERSITY
- Study coordinator: JIMAH, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers