Understanding how Dusp4 affects muscle health
Official title: The Functional Role of Dusp4 in Skeletal Muscle
Funded at University of North Florida · NIH-11137117 · Data updated 2026-11-12
This study is looking at a protein called Dusp4 to see how it affects muscle growth and loss, especially when muscles shrink, and it aims to find ways to help keep your muscles healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Florida NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | July 15, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $180,007 |
| NIH project number | 5R16GM154710-02 |
| Project ID | NIH-11137117 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing muscle atrophy due to aging, injury, or neurological conditions.
✕Less likely to help
Patients with stable muscle mass and no underlying conditions affecting muscle health may not benefit from this research.
What this research studies
This research investigates the role of Dusp4, a protein that may influence muscle growth and wasting. It focuses on how Dusp4 interacts with signaling pathways in skeletal muscle, particularly during conditions like atrophy when muscle mass decreases. By analyzing gene expression in muscle tissue, the study aims to uncover how Dusp4's regulation of these pathways can impact muscle health. This could lead to new insights into maintaining muscle mass in various conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing muscle loss and improving muscle health in patients.
How similar studies have gone: Previous research has shown promising results in understanding muscle signaling pathways, making this approach potentially impactful.
Where this research is happening
-
University of North Florida
Jacksonville, United States Active
Researchers
- Principal investigator: Waddell, David Scott — University of North Florida
- Study coordinator: Waddell, David Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.