Understanding how DUSP12 affects cell division and death in cancer cells.
Official title: Defining the role of DUSP12 in the regulation of cell division and apoptosis.
Funded at University of California Los Angeles · NIH-10901543 · Data updated 2026-11-12
This study is looking at a protein called DUSP12 to see how it affects cell growth and death in cancer cells, with the hope that understanding this could help develop better treatments for cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 11, 2024 |
| Project end | January 10, 2026 |
| Funding year | 2024 |
| Award (this year) | $41,027 |
| NIH project number | 1F31GM154466-01 |
| Project ID | NIH-10901543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that exhibit abnormal cell division and proliferation.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers do not involve the mechanisms being studied may not benefit from this research.
What this research studies
This research investigates the role of a protein called DUSP12 in regulating cell division and apoptosis, which is the process of programmed cell death. By using cancer cell lines, the researchers aim to understand how DUSP12 influences these critical cellular processes. They will employ advanced techniques such as RNA interference and mass spectrometry to identify interactions between DUSP12 and other proteins, particularly ZPR9, which may play a role in both cell survival and death. The goal is to uncover new insights that could lead to better cancer treatments by targeting these pathways.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancer by targeting the mechanisms of cell division and apoptosis.
How similar studies have gone: Previous research has shown success in targeting similar cellular pathways in cancer treatment, indicating potential for this approach.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Abdusamad, Mai — University of California Los Angeles
- Study coordinator: Abdusamad, Mai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.