Understanding how drugs penetrate the brain and brain tumors
Physiologically Based Pharmacokinetic Modeling of Drug Penetration into the Human Brain and Brain Tumors
['FUNDING_R01'] · WAYNE STATE UNIVERSITY · NIH-10914011
This study is looking at how well different medications can get into the brain to help treat brain tumors, so that doctors can find better ways to deliver these treatments to patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10914011 on ClinicalTrials.gov |
What this research studies
This research investigates how drugs can effectively cross the blood-brain barrier (BBB) to treat brain tumors. It focuses on developing a physiologically based pharmacokinetic (PBPK) model that predicts how different drugs penetrate the BBB and the disrupted barriers found in brain tumors. By using this model, researchers aim to better understand the variability in drug exposure among patients, which can lead to more effective treatments for brain cancer. The approach combines laboratory data with biological characteristics to enhance drug delivery predictions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with brain tumors who are seeking innovative treatment options.
Not a fit: Patients with conditions unrelated to brain tumors or those who do not require drug treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug delivery methods for treating brain tumors, potentially enhancing treatment outcomes for patients.
How similar studies have performed: Other research has shown promise in using pharmacokinetic modeling to improve drug delivery to the brain, indicating that this approach has potential for success.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, JING — WAYNE STATE UNIVERSITY
- Study coordinator: LI, JING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents