Understanding how drugs of abuse affect HIV infection
A machine learning framework for understanding impacts on the HIV latent reservoir size, including drugs of abuse
This study is looking at how things like recreational drug use, especially cannabis, might affect the hidden HIV reservoir in people living with HIV, to help find better treatment options in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10877882 on NIH RePORTER |
What this research studies
This research investigates the factors that influence the size of the HIV latent reservoir, which is a major barrier to curing HIV. It focuses on how recreational drug use, particularly cannabinoids, may affect this reservoir in individuals living with HIV. By utilizing advanced machine learning techniques, the study aims to analyze complex interactions between host genetics, immune responses, and environmental factors. The goal is to develop a deeper understanding of these interactions to inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may also use recreational drugs, particularly cannabinoids.
Not a fit: Patients who are not living with HIV or do not use recreational drugs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HIV and potentially reducing the size of the latent reservoir.
How similar studies have performed: While the specific interactions between cannabinoids and the HIV reservoir are not fully explored, similar research approaches have shown promise in understanding complex biological interactions.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Rudin, Cynthia — Duke University
- Study coordinator: Rudin, Cynthia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.