Understanding how drugs fight Trypanosomatid infections
Dissecting multidrug resistance pathways in Trypanosomatids
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11230554
This study is looking into how current medications fight off parasites that cause diseases like African sleeping sickness and Leishmaniasis, with the goal of finding better treatments for the millions of people affected by these illnesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11230554 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which existing anti-trypanosomatid drugs kill parasites responsible for diseases like African sleeping sickness and Leishmaniasis. It aims to uncover the pathways of drug resistance and cell death in these parasites, which affect over a billion people worldwide. By utilizing advanced genetic tools, the study seeks to identify the specific genes involved in drug resistance, potentially leading to the development of more effective treatments. The findings could help improve current therapies and inform the creation of new drugs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from Trypanosomatid infections, such as those with African sleeping sickness or Leishmaniasis.
Not a fit: Patients with other types of infections or diseases unrelated to Trypanosomatids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Trypanosomatid infections, improving health outcomes for millions of affected individuals.
How similar studies have performed: Previous research has shown success in identifying drug resistance mechanisms in similar parasites, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOVEL-MINER, GALADRIEL ASTRA — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: HOVEL-MINER, GALADRIEL ASTRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.