Understanding how drugs can prevent heart muscle growth that leads to heart failure
Systems Pharmacology Model of Cardiac Hypertrophy
This study is looking at how certain FDA-approved medications might help prevent or treat heart muscle enlargement, which can lead to heart failure, by testing them in the lab and in animals to find the best options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11042814 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cardiac hypertrophy, which is the enlargement of heart muscle cells that can lead to heart failure. By using a systems pharmacology approach, the study aims to identify existing FDA-approved drugs that could be repurposed to prevent or treat this condition. The researchers will analyze how different drugs and their combinations affect heart muscle cells in both laboratory settings and animal models. This comprehensive approach seeks to find effective therapies that can intervene early in the disease process to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk of developing heart failure due to cardiac hypertrophy, such as those with hypertension or other cardiovascular conditions.
Not a fit: Patients who already have advanced heart failure or those without any signs of cardiac hypertrophy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that prevent the progression of cardiac hypertrophy and reduce the risk of heart failure in patients.
How similar studies have performed: Previous research has shown promise in using systems pharmacology approaches to identify drug interactions, suggesting that this method could be effective in addressing cardiac hypertrophy.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Saucerman, Jeffrey J. — University of Virginia
- Study coordinator: Saucerman, Jeffrey J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.