Understanding how drug use affects lipid signaling in the body
Official title: Bioactive Lipid Mediators Core (BLMC)
Funded at Trustees of Indiana University · NIH-10898850 · Data updated 2026-11-12
This study is looking at how long-term drug use affects fats in the body, especially in the brain and blood, to help us understand addiction better and find new ways to treat it.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $323,513 |
| NIH project number | 5P30DA056410-02 |
| Project ID | NIH-10898850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with a history of substance use disorders or those interested in the biological effects of drug use.
✕Less likely to help
Patients who are not affected by substance use disorders or those without a history of drug use may not receive benefit from this research.
What this research studies
The Bioactive Lipid Mediators Core (BLMC) investigates the effects of chronic drug use on lipid signaling across various tissues, including the central nervous system and plasma. By analyzing lipid biomarkers, the research aims to uncover how these changes relate to drug use disorders and homeostatic dysregulation. Using animal models, the study evaluates lipidomic patterns in response to substances like THC, opioids, and alcohol, which could lead to new therapeutic approaches for treating addiction. The research employs advanced lipid extraction and analytical techniques to gain insights into the systemic and neurophysiological outcomes of drug exposure.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies for treating drug addiction by understanding lipid signaling changes.
How similar studies have gone: Other research has shown promise in understanding lipid signaling related to drug use, suggesting that this approach could yield significant insights.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Bradshaw, Heather Bryte — Trustees of Indiana University
- Study coordinator: Bradshaw, Heather Bryte
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.