Understanding how drug transport works during pregnancy
Investigating the molecular mechanism of P-gp/NHERF-1 network at feto maternal interface and role of paracrine signaling of EVs containing drug transporter proteins
This study is looking at how certain proteins help move medications across the placenta during pregnancy, using advanced technology to better understand these processes, with the goal of improving treatment options for pregnant people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-11103352 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of drug transport at the feto-maternal interface, focusing on how certain proteins interact to influence drug delivery during pregnancy. It aims to explore the role of sodium hydrogen exchange regulatory factor-1 (NHERF-1) and permeability glycoprotein (P-gp) in this process, particularly in the fetal membranes. The study will utilize innovative organ-on-chip technology to model these interactions and assess how extracellular vesicles carrying drug transporter proteins affect maternal cells. By gaining insights into these mechanisms, the research seeks to improve pharmacotherapy outcomes for pregnant individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals who may require pharmacotherapy for managing health conditions during pregnancy.
Not a fit: Patients who are not pregnant or those not requiring medication during pregnancy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug delivery strategies during pregnancy, enhancing maternal and neonatal health outcomes.
How similar studies have performed: While the specific approach of targeting NHERF-1 in this context is novel, related research has shown promise in understanding drug transport mechanisms during pregnancy.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Kammala, Ananth Kumar — University of Texas Med Br Galveston
- Study coordinator: Kammala, Ananth Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.