Understanding how drug-resistant tuberculosis spreads in South Africa
Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection
This study is looking at how drug-resistant tuberculosis spreads in South Africa and aims to find new ways to spot and stop these infections early, helping to keep communities safe.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10897057 on NIH RePORTER |
What this research studies
This research investigates the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis in South Africa, a region particularly vulnerable to such infections. By utilizing geolocated microbial genomic data and mobile phone movement data, the study aims to develop innovative strategies for early detection and containment of these strains before they escalate into larger outbreaks. The principal investigator, an infectious disease physician and epidemiologist, will also receive training in advanced statistical methods and network science to enhance the effectiveness of the research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals in South Africa who are at risk of or currently infected with drug-resistant tuberculosis.
Not a fit: Patients outside of South Africa or those with non-tuberculosis related infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and management of drug-resistant tuberculosis, ultimately saving lives and reducing transmission rates.
How similar studies have performed: Previous research has shown success in using genomic and mobility data to track infectious disease outbreaks, indicating that this approach has potential for significant impact.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Brown, Tyler Steven — Boston Medical Center
- Study coordinator: Brown, Tyler Steven
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.