Understanding how drug-resistant Candida auris colonizes human skin
Pathogen and immune-topographic mechanisms that underpin Candida auris skin colonization
This project looks at how the drug-resistant fungus Candida auris sticks to human skin, which helps it spread and cause infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11141808 on NIH RePORTER |
What this research studies
Candida auris is a tough, drug-resistant fungus that easily spreads from person to person by colonizing skin. We currently don't have good ways to stop this colonization, and we don't fully understand how C. auris interacts with skin. This project uses laboratory models to explore how C. auris attaches to skin and how the body's immune system responds. By learning more about these interactions, we hope to find new ways to prevent or reverse skin colonization.
Who could benefit from this research
Good fit: Patients who are at risk for or currently dealing with Candida auris skin colonization could potentially benefit from future treatments developed from this research.
Not a fit: Patients whose conditions are not related to Candida auris skin colonization would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies to prevent the spread of drug-resistant Candida auris and reduce serious infections.
How similar studies have performed: This research builds upon preliminary findings in mouse models, but the specific mechanisms of C. auris skin colonization are not well understood, making this a novel area of focus.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Noble, Suzanne M — University of California, San Francisco
- Study coordinator: Noble, Suzanne M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.