Understanding how drug-resistant bacteria affect critically ill and immunocompromised patients
Dynamics of Colonization and Infection by Multidrug-resistant Pathogens in Immunocompromised and Critically Ill Patients (DYNAMITE)
This study is looking at how certain tough germs can take over the intestines and cause serious infections in critically ill patients or those with weakened immune systems, with the goal of finding better ways to treat and protect these patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10450736 on NIH RePORTER |
What this research studies
This research investigates the dynamics of colonization and infection by multidrug-resistant pathogens, particularly in patients who are critically ill or have weakened immune systems. It focuses on understanding how these pathogens, such as vancomycin-resistant enterococci and Clostridioides difficile, colonize the intestines and how their presence can lead to severe infections. The study aims to identify high-risk patients and explore the interactions between different pathogens in the gut, which could help in developing better treatment strategies. By analyzing microbiome data, the research seeks to provide insights that could lead to more effective interventions for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill patients or those with compromised immune systems who are at risk of infections from multidrug-resistant pathogens.
Not a fit: Patients who are not critically ill or do not have compromised immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management of infections caused by multidrug-resistant bacteria in vulnerable patient populations.
How similar studies have performed: Previous research has shown promising results in understanding the dynamics of gut microbiota and its impact on infections, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Arias, Cesar Augusto — Methodist Hospital Research Institute
- Study coordinator: Arias, Cesar Augusto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.