Understanding how drug resistance develops in acute myeloid leukemia.
Molecular mechanisms of drug resistance and disease progression in acute myeloid leukemia.
['FUNDING_OTHER'] · JESSE BROWN VA MEDICAL CENTER · NIH-10873170
This study is looking at how certain gene changes in people with acute myeloid leukemia (AML) might make the disease harder to treat and help it grow, with the goal of finding new ways to improve treatments and outcomes for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JESSE BROWN VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10873170 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms that lead to drug resistance and disease progression in acute myeloid leukemia (AML). It focuses on how mutations in certain genes can activate the innate immune response, potentially contributing to the development of leukemia. By studying these mechanisms in both human patients and mouse models, the research aims to identify new targets for treatment and improve patient outcomes. The approach includes analyzing genetic mutations and their effects on immune responses and leukemia progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or myelodysplastic syndromes who may be experiencing drug resistance.
Not a fit: Patients with other types of leukemia or those who do not have acute myeloid leukemia or myelodysplastic syndromes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with acute myeloid leukemia by overcoming drug resistance.
How similar studies have performed: Previous research has shown success in understanding drug resistance mechanisms in other cancers, suggesting that this approach may yield valuable insights for AML as well.
Where this research is happening
CHICAGO, UNITED STATES
- JESSE BROWN VA MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EKLUND, ELIZABETH ANN — JESSE BROWN VA MEDICAL CENTER
- Study coordinator: EKLUND, ELIZABETH ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.