Understanding how drug addiction affects brain function
Transcriptional Mechanisms of Drug Addiction
This study is looking at how addiction to stimulants and opioids affects the brain, focusing on changes in certain genes and brain areas that control reward and behavior, to help find better treatments for people struggling with addiction.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11158852 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms behind addiction to stimulants and opioids by examining specific brain regions involved in reward and behavior. The team utilizes advanced techniques in transcriptional biology to explore how certain genes and cellular responses are altered in individuals with addiction. By studying both animal models and human brain tissue, the research aims to uncover lasting changes in the brain that contribute to addictive behaviors. The findings could lead to new insights into potential treatments for addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of addiction to stimulants or opioids.
Not a fit: Patients who do not have a history of substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for individuals struggling with stimulant and opioid addiction.
How similar studies have performed: Previous research has shown promising results in understanding the biological underpinnings of addiction, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Nestler, Eric J. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Nestler, Eric J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.