Understanding how Draxin affects the development of cranial neural crest cells
Characterization of the roles and regulation of Draxin in cranial neural crest
This study is looking at how a protein called Draxin affects the development of cells that help form the face, which could help us understand and find new treatments for conditions like Treacher Collins syndrome.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11106070 on NIH RePORTER |
What this research studies
This research investigates the role of Draxin, a Wnt pathway antagonist, in the development of cranial neural crest (NC) cells, which are crucial for forming facial structures. By examining how Draxin regulates the timing of epithelial-to-mesenchymal transition (EMT) in NC cells, the study aims to uncover the mechanisms behind craniofacial abnormalities. The approach includes analyzing the effects of Draxin on NC cell migration and differentiation, which could lead to insights into various craniofacial syndromes. Patients with conditions like Treacher Collins syndrome may benefit from the findings as they could help identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with craniofacial syndromes such as Treacher Collins syndrome or other related conditions.
Not a fit: Patients without craniofacial abnormalities or those not affected by neural crest development issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for craniofacial abnormalities associated with neural crest development.
How similar studies have performed: Previous research has shown success in understanding the roles of signaling pathways in craniofacial development, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Hutchins, Erica — University of California, San Francisco
- Study coordinator: Hutchins, Erica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.