Understanding how Draxin affects cranial neural crest development
Characterization of the roles and regulation of Draxin in cranial neural crest
This study is looking at how a protein called Draxin affects the development of cells that help form the face, with the goal of understanding why some people have facial abnormalities.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10851796 on NIH RePORTER |
What this research studies
This research investigates the role of Draxin, a Wnt pathway antagonist, in the development of cranial neural crest cells, which are crucial for forming facial structures. By studying how Draxin regulates the timing of epithelial-to-mesenchymal transition (EMT) in these cells, the research aims to uncover the mechanisms behind craniofacial abnormalities. The approach involves examining the molecular pathways and regulatory changes that influence cranial neural crest migration and differentiation. This could lead to insights into various conditions linked to craniofacial malformations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by craniofacial abnormalities, particularly those linked to neural crest development issues.
Not a fit: Patients with craniofacial conditions not related to neural crest development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new understanding and potential therapeutic targets for craniofacial abnormalities associated with conditions like Treacher Collins syndrome.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling pathways in craniofacial development, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Hutchins, Erica — University of California, San Francisco
- Study coordinator: Hutchins, Erica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.