Understanding how Down syndrome affects Alzheimer's disease
Toward a neuroscientific understanding of the interaction between Down syndrome and Alzheimer's disease pathology
This study is looking at how Down syndrome and Alzheimer's disease are connected, using special brain scans to find out how the brains of people with Down syndrome change as they get older, so we can help catch Alzheimer's early and support those at risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11101250 on NIH RePORTER |
What this research studies
This research investigates the relationship between Down syndrome and Alzheimer's disease by using advanced neuroimaging techniques and biomarkers. It aims to identify brain changes and neuropsychological patterns in individuals with Down syndrome as they age, particularly focusing on the onset of Alzheimer's disease. By analyzing brain connectivity and microstructure through MRI and other methods, the study seeks to uncover critical information that could lead to early interventions before significant cognitive decline occurs. This research is particularly relevant for individuals with Down syndrome, who have a high risk of developing Alzheimer's disease as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Down syndrome, particularly those over the age of 40, who may be at risk for Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and targeted interventions for individuals with Down syndrome at risk of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding neurodegenerative diseases in populations with genetic predispositions, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Bruno, Jennifer L — Stanford University
- Study coordinator: Bruno, Jennifer L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.