Understanding how double-stranded RNA affects immune responses
Elucidating roles and mechanisms of double-stranded RNA-mediated pathways
This study is looking at how our bodies tell the difference between our own natural RNA and the RNA from viruses, which can trigger immune responses, using tiny worms as a model to learn more about the proteins that help manage this process, and the findings could help us better understand how to fight off viral infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11042763 on NIH RePORTER |
What this research studies
This research investigates the roles and mechanisms of long double-stranded RNA (dsRNA) in animals, including humans, focusing on how the body distinguishes between its own dsRNA and viral dsRNA that triggers immune responses. Using the model organism C. elegans, researchers will explore the proteins and enzymes, such as ADARs and Dicer, that modify and process dsRNA to prevent inappropriate immune activation. The study employs genetic and biochemical methods to uncover the underlying mechanisms of these processes, which could have implications for understanding antiviral defenses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to viral infections or immune response dysregulation.
Not a fit: Patients with non-viral related conditions or those not experiencing immune response issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing antiviral responses and improving treatments for viral infections.
How similar studies have performed: Previous studies have shown success in understanding RNA-mediated immune responses, but this specific approach using C. elegans is relatively novel.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Bass, Brenda L. — University of Utah
- Study coordinator: Bass, Brenda L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.