Understanding how double mutations in the PIK3CA gene affect breast cancer treatment
Investigating a hierarchical model for PI3K activation and inhibition in breast cancer by double PIK3CA mutations in cis
This study is looking at how certain changes in the PIK3CA gene affect breast cancer growth and treatment, with the goal of finding better, more personalized therapies for patients with this type of cancer.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10871712 on NIH RePORTER |
What this research studies
This research investigates the role of double mutations in the PIK3CA gene, which is commonly altered in breast cancer. By examining how these mutations activate cancer growth and influence the effectiveness of PI3Kα inhibitors, the study aims to improve treatment strategies for patients with PIK3CA mutant breast cancer. The researchers will utilize advanced cellular models to explore the mechanisms behind these mutations and their interactions with other cancer-related pathways. This could lead to more personalized and effective therapies for patients with specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with ER+ metastatic breast cancer who have PIK3CA mutations.
Not a fit: Patients without PIK3CA mutations or those with other types of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with breast cancer harboring double PIK3CA mutations.
How similar studies have performed: Previous research has shown promising results in targeting PIK3CA mutations in breast cancer, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Vasan, Neil — Columbia University Health Sciences
- Study coordinator: Vasan, Neil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.